Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma

• Main Authors: Amanda Thomaz (Author), Kelly de Vargas Pinheiro (Author), Bárbara Kunzler Souza (Author), Lauro Gregianin (Author), Algemir L. Brunetto (Author), André T. Brunetto (Author), Caroline Brunetto de Farias (Author), Mariane da Cunha Jaeger (Author), Vijay Ramaswamy (Author), Carolina Nör (Author), Michael D. Taylor (Author), Rafael Roesler (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neurotrophins are critically involved in regulating normal neural development and plasticity. Brain-derived neurotrophic factor (BDNF), a neurotrophin that acts by binding to the tropomyosin receptor kinase B (TrkB) receptor, has also been implicated in the progression of several types of cancer. Ho...