Cyclosporin A-induced gingival overgrowth is not associated with myofibroblast transdifferentiation

• Main Authors: Lays Martin Sobral (Author), Michele Gassen Kellermann (Author), Edgard Graner (Author), Hercilio Martelli-Junior (Author), Ricardo Della Coletta (Author)
• Format: Book
• Published: Sociedade Brasileira de Pesquisa Odontológica, 2010-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cyclosporin A (CyA) induces gingival overgrowth via its stimulatory effects on expression of transforming growth factor-beta1 (TGF-β1) and collagen. It is not known whether CyA has a direct effect on gingival fibroblasts or induces its effect indirectly via stimulation of myofibroblast transdifferen...