Melatonin-loaded lipid-core nanocapsules protect against lipid peroxidation caused by paraquat through increased SOD expression in Caenorhabditis elegans

• Egile Nagusiak: Mariele F. Charão (Egilea), Gabriela Goethel (Egilea), Natália Brucker (Egilea), Karina Paese (Egilea), Vera L. Eifler-Lima (Egilea), Adriana R. Pohlmann (Egilea), Silvia S. Guterres (Egilea), Solange C. Garcia (Egilea)
• Formatua: Liburua
• Argitaratua: BMC, 2019-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract Background Melatonin has been described in the literature as a potent antioxidant. However, melatonin presents variable, low bioavailability and a short half-life. The use of polymeric nanoparticulated systems has been proposed for controlled release. Thus, the purpose of this study was to...