Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan

• Main Authors: Jun Yamada (Author), Kunikazu Tsuji (Author), Kazumasa Miyatake (Author), Yu Matsukura (Author), Kahaer Abula (Author), Makiko Inoue (Author), Ichiro Sekiya (Author), Takeshi Muneta (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activins are proinflammatory cytokines which belong to the TGFβ superfamily. Follistatin is an extracellular decoy receptor for activins. Since both activins and follistatin are expressed in articular cartilage, we hypothesized that activin-follistatin signaling participates in the process of joint...