From Synthesis to Characterization of Site-Selective PEGylated Proteins

• Main Authors: Lisandra Herrera Belén (Author), Carlota de Oliveira Rangel-Yagui (Author), Jorge F. Beltrán Lissabet (Author), Brian Effer (Author), Manuel Lee-Estevez (Author), Adalberto Pessoa (Author), Rodrigo L. Castillo (Author), Jorge G. Farías (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Covalent attachment of therapeutic proteins to polyethylene glycol (PEG) is widely used for the improvement of its pharmacokinetic and pharmacological properties, as well as the reduction in reactogenicity and related side effects. This technique named PEGylation has been successfully employed in se...