Exploring Pediatric Vertebral, Sacral, and Pelvic Osteosarcomas through the NCDB: Demographics, Treatment Utilization, and Survival Outcomes

• Main Authors: Pemla Jagtiani (Author), Mert Karabacak (Author), Matthew T. Carr (Author), Zeynep Bahadir (Author), Peter F. Morgenstern (Author), Konstantinos Margetis (Author)
• Format: Book
• Published: MDPI AG, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Background and Objectives: Retrieve data from the National Cancer Database (NCDB) to examine information on the epidemiological prevalence, treatment strategies, and survival outcomes of pediatric vertebral, sacral and pelvic osteosarcomas. Methods: We reviewed NCDB data from 2008 to 2018, concentrating on vertebral, sacral, and pelvic osteosarcomas in children 0 to 21 years. Our analysis involved logistic and Poisson regression, Kaplan-Meier survival estimates, and Cox proportional hazards models. Results: The study population included 207 patients. For vertebral osteosarcomas, 62.5% of patients were female, and 78.1% were white. Regional lymph node involvement predicted 80 times higher mortality hazard (<i>p</i> = 0.021). Distant metastasis predicted 25 times higher mortality hazard (<i>p</i> = 0.027). For sacral and pelvic osteosarcomas, 58.3% of patients were male, and 72% were white. Patients with residual tumor were 4 times more likely to have prolonged LOS (<i>p</i> = 0.031). No residual tumor (HR = 0.53, <i>p</i> = 0.03) and radiotherapy receipt (HR = 0.46, <i>p</i> = 0.034) were associated with lower mortality hazards. Distant metastasis predicted 3 times higher mortality hazard (<i>p</i> < 0.001). Hispanic ethnicity was linked to lower resection odds (OR = 0.342, <i>p</i> = 0.043), possibly due to language barriers affecting patient understanding and care decisions. Conclusions: In conclusion, our examination of NCDB offers a thorough exploration of demographics, treatment patterns, and results, highlighting the importance of personalized approaches to enhance patient outcomes.

Item Description

10.3390/children11081025
2227-9067