Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation

• Main Authors: Chi Ma (Author), FuKun W. Hoffmann (Author), Michael P. Marciel (Author), Kathleen E. Page (Author), Melodie A. Williams-Aduja (Author), Ellis N.L. Akana (Author), Greg S. Gojanovich (Author), Mariana Gerschenson (Author), Johann Urschitz (Author), Stefan Moisyadi (Author), Vedbar S. Khadka (Author), Sharon Rozovsky (Author), Youping Deng (Author), F. David Horgen (Author), Peter R. Hoffmann (Author)
• Format: Book
• Published: Elsevier, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: T cell activation triggers metabolic reprogramming to meet increased demands for energy and metabolites required for cellular proliferation. Ethanolamine phospholipid synthesis has emerged as a regulator of metabolic shifts in stem cells and cancer cells, which led us to investigate its p...