Development and Evaluation of Self-Microemulsifying Drug Delivery System for Improving Oral Absorption of Poorly Water-Soluble Olaparib

• Main Authors: Yong-Han Kim (Author), Seong-Bo Kim (Author), Se-Hee Choi (Author), Thi- (Author), Sung-Hoon Ahn (Author), Kyung-Sun Moon (Author), Kwan-Hyung Cho (Author), Tae-Yong Sim (Author), Eun-Ji Heo (Author), Sung Tae Kim (Author), Hyun-Suk Jung (Author), Jun-Pil Jee (Author), Han-Gon Choi (Author), Dong-Jin Jang (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of this study is to develop and evaluate a self-microemulsifying drug delivery system (SMEDDS) to improve the oral absorption of poorly water-soluble olaparib. Through the solubility test of olaparib in various oils, surfactants and co-surfactants, pharmaceutical excipients were selected...