Anti-hyperalgesic and anti-inflammatory effects of 4R-tobacco cembranoid in a mouse model of inflammatory pain

• Main Authors: Luis G. Rivera-García (Author), Adela M. Francis-Malavé (Author), Zachary W. Castillo (Author), Calvin D. Uong (Author), Torri D. Wilson (Author), P. A. Ferchmin (Author), Vesna Eterovic (Author), Michael D. Burton (Author), Yarimar Carrasquillo (Author)
• Format: Book
• Published: BMC, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract 4R is a tobacco cembranoid that binds to and modulates cholinergic receptors and exhibits neuroprotective and anti-inflammatory activity. Given the established function of the cholinergic system in pain and inflammation, we propose that 4R is also analgesic. Here, we tested the hypothesis t...