T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways

• Main Authors: Kathleen Smith (Author), Elnaz Karimian Azari (Author), Traci E. LaMoia (Author), Tania Hussain (Author), Veronika Vargova (Author), Katalin Karolyi (Author), Paula P. Veldhuis (Author), Juan Pablo Arnoletti (Author), Sebastian G. de la Fuente (Author), Richard E. Pratley (Author), Timothy F. Osborne (Author), George A. Kyriazis (Author)
• Format: Book
• Published: Elsevier, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Beyond the taste buds, sweet taste receptors (STRs; T1R2/T1R3) are also expressed on enteroendocrine cells, where they regulate gut peptide secretion but their regulatory function within the intestine is largely unknown. Methods: Using T1R2-knock out (KO) mice we evaluated the role of STR...