One-pot and one-step automated radio-synthesis of [18F]AlF-FAPI-74 using a multi purpose synthesizer: a proof-of-concept experiment

• Main Authors: Sadahiro Naka (Author), Tadashi Watabe (Author), Thomas Lindner (Author), Jens Cardinale (Author), Kenta Kurimoto (Author), Melissa Moore (Author), Mitsuaki Tatsumi (Author), Yuriko Mori (Author), Eku Shimosegawa (Author), Frank Valla (Author), Hiroki Kato (Author), Frederik L. Giesel (Author)
• Format: Book
• Published: SpringerOpen, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Fibroblast activation protein (FAP) is overexpressed in the stroma of many types of cancer. [18F]AlF-FAPI-74 is a positron emission tomography tracer with high selectivity for FAP, which has already shown high accumulation within human tumors in clinical studies. However, [18F]Al...