A standardised Phase III clinical trial framework to assess therapeutic interventions for Lassa fever.

• Main Authors: Adebola Tolulope Olayinka (Author), Josephine Bourner (Author), George O Akpede (Author), Joseph Okoeguale (Author), Chukwuyem Abejegah (Author), Nnennaya A Ajayi (Author), Christian Akude (Author), Oluwafemi Ayodeji (Author), Daniel G Bausch (Author), Hilde de Clerck (Author), Chioma Dan-Nwafor (Author), Jake Dunning (Author), Cyril Erameh (Author), Justus Ndulue Eze (Author), Pierre Formenty (Author), Annelies Gillesen (Author), Sulaiman Jalloh (Author), Marie Jaspard (Author), Tolulope Jegede (Author), Jacob Maikere (Author), Denis Malvy (Author), Ephraim Ogbaini-Emovon (Author), Olalekan Ezekial Ojo (Author), Sylvanus Okogbenin (Author), Kwame O'Neill (Author), Maria-Lauretta Orji (Author), Sampson Omagbemi Owhin (Author), Michael Ramharter (Author), Robert J Samuels (Author), Nathan Shehu (Author), Laura Merson (Author), Alex Paddy Salam (Author), Nzelle Delphine Kayem (Author), Peter Horby (Author), Chikwe Ihekweazu (Author), Piero Olliaro (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Only one recommendation currently exists for the treatment of Lassa fever (LF), which is ribavirin administered in conjunction with supportive care. This recommendation is primarily based on evidence generated from a single clinical trial that was conducted more than 3...