Human ACVR1C missense variants that correlate with altered body fat distribution produce metabolic alterations of graded severity in knock-in mutant mice

Background & aims: Genome-wide studies have identified three missense variants in the human gene ACVR1C, encoding the TGF-β superfamily receptor ALK7, that correlate with altered waist-to-hip ratio adjusted for body mass index (WHR/BMI), a measure of body fat distribution. Methods: To move from...

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Main Authors: Pawanrat Tangseefa (Author), Hong Jin (Author), Houyu Zhang (Author), Meng Xie (Author), Carlos F. Ibáñez (Author)
Format: Book
Published: Elsevier, 2024-03-01T00:00:00Z.
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