Human ACVR1C missense variants that correlate with altered body fat distribution produce metabolic alterations of graded severity in knock-in mutant mice

• 主要な著者: Pawanrat Tangseefa (著者), Hong Jin (著者), Houyu Zhang (著者), Meng Xie (著者), Carlos F. Ibáñez (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2024-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Background & aims: Genome-wide studies have identified three missense variants in the human gene ACVR1C, encoding the TGF-β superfamily receptor ALK7, that correlate with altered waist-to-hip ratio adjusted for body mass index (WHR/BMI), a measure of body fat distribution. Methods: To move from...