Human ACVR1C missense variants that correlate with altered body fat distribution produce metabolic alterations of graded severity in knock-in mutant mice

• Váldodahkkit: Pawanrat Tangseefa (Dahkki), Hong Jin (Dahkki), Houyu Zhang (Dahkki), Meng Xie (Dahkki), Carlos F. Ibáñez (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2024-03-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Background & aims: Genome-wide studies have identified three missense variants in the human gene ACVR1C, encoding the TGF-β superfamily receptor ALK7, that correlate with altered waist-to-hip ratio adjusted for body mass index (WHR/BMI), a measure of body fat distribution. Methods: To move from...