Checkpoint inhibitor blockade and epigenetic reprogrammability in CD8 T-cell activation and exhaustion

• Main Authors: José Belizário (Author), Maria Fernanda Destro Rodrigues (Author)
• פורמט: ספר
• יצא לאור: SAGE Publishing, 2020-03-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

CD8 + T-cell exhaustion is a dysfunctional state that is regulated through the expression of inhibitory checkpoint receptor genes including the cytotoxic T-lymphocyte-associated antigen 4, programmed death 1, and DNA methylation of effector genes interferon-γ, perforin, and granzyme B. Different str...