Checkpoint inhibitor blockade and epigenetic reprogrammability in CD8 T-cell activation and exhaustion
CD8 + T-cell exhaustion is a dysfunctional state that is regulated through the expression of inhibitory checkpoint receptor genes including the cytotoxic T-lymphocyte-associated antigen 4, programmed death 1, and DNA methylation of effector genes interferon-γ, perforin, and granzyme B. Different str...
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SAGE Publishing,
2020-03-01T00:00:00Z.
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