PXR activation impairs hepatic glucose metabolism partly via inhibiting the HNF4α-GLUT2 pathway
Drug-induced hyperglycemia/diabetes is a global issue. Some drugs induce hyperglycemia by activating the pregnane X receptor (PXR), but the mechanism is unclear. Here, we report that PXR activation induces hyperglycemia by impairing hepatic glucose metabolism due to inhibition of the hepatocyte nucl...
Bewaard in:
Hoofdauteurs: | , , , , , , , , , , , , , , |
---|---|
Formaat: | Boek |
Gepubliceerd in: |
Elsevier,
2022-05-01T00:00:00Z.
|
Onderwerpen: | |
Online toegang: | Connect to this object online. |
Tags: |
Voeg label toe
Geen labels, Wees de eerste die dit record labelt!
|
Internet
Connect to this object online.3rd Floor Main Library
Plaatsingsnummer: |
A1234.567 |
---|---|
Kopie 1 | Beschikbaar |