PXR activation impairs hepatic glucose metabolism partly via inhibiting the HNF4α-GLUT2 pathway
Drug-induced hyperglycemia/diabetes is a global issue. Some drugs induce hyperglycemia by activating the pregnane X receptor (PXR), but the mechanism is unclear. Here, we report that PXR activation induces hyperglycemia by impairing hepatic glucose metabolism due to inhibition of the hepatocyte nucl...
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Main Authors: | , , , , , , , , , , , , , , |
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Format: | Book |
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Elsevier,
2022-05-01T00:00:00Z.
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A1234.567 |
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