PXR activation impairs hepatic glucose metabolism partly via inhibiting the HNF4α-GLUT2 pathway

• Main Authors: Peihua Liu (Author), Ling Jiang (Author), Weimin Kong (Author), Qiushi Xie (Author), Ping Li (Author), Xiaonan Liu (Author), Jiayi Zhang (Author), Ming Liu (Author), Zhongjian Wang (Author), Liang Zhu (Author), Hanyu Yang (Author), Ying Zhou (Author), Jianjun Zou (Author), Xiaodong Liu (Author), Li Liu (Author)
• Format: Book
• Published: Elsevier, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug-induced hyperglycemia/diabetes is a global issue. Some drugs induce hyperglycemia by activating the pregnane X receptor (PXR), but the mechanism is unclear. Here, we report that PXR activation induces hyperglycemia by impairing hepatic glucose metabolism due to inhibition of the hepatocyte nucl...