Formulation Strategies to Improve Nose-to-Brain Delivery of Donepezil

• Main Authors: Lupe Carolina Espinoza (Author), Marcelle Silva-Abreu (Author), Beatriz Clares (Author), María José Rodríguez-Lagunas (Author), Lyda Halbaut (Author), María-Alexandra Cañas (Author), Ana Cristina Calpena (Author)
• Format: Book
• Published: MDPI AG, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Donepezil (DPZ) is widely used in the treatment of Alzheimer’s disease in tablet form for oral administration. The pharmacological efficacy of this drug can be enhanced by the use of intranasal administration because this route makes bypassing the blood⁻brain barrier (BBB) possible. The aim of this...