Effects of Tamoxifen on L-Glutamate Transporters of Astrocytes

• Main Authors: Kaoru Sato (Author), Yoshihiko Saito (Author), Jun-ichiro Oka (Author), Tomohiko Ohwada (Author), Ken Nakazawa (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tamoxifen (Tam) decreased the clearance of L-glutamate (L-Glu) by cultured astrocytes at 1 pM, 1 nM, and 1 μM, but became toxic at 10 μM. When L-Glu transporters were mostly inhibited by threo-β-benzyloxyaspartate (TBOA) (1 mM) or D,L-threo-β-hydroxyaspartate (THA) (1 mM), Tam (1 nM) did not change...