Sildenafil 4.0-Integrated Synthetic Chemistry, Formulation and Analytical Strategies Effecting Immense Therapeutic and Societal Impact in the Fourth Industrial Era

• Main Authors: Andreas Ouranidis (Author), Anastasia Tsiaxerli (Author), Elisavet Vardaka (Author), Catherine K. Markopoulou (Author), Constantinos K. Zacharis (Author), Ioannis Nicolaou (Author), Dimitris Hatzichristou (Author), Anna-Bettina Haidich (Author), Nikolaos Kostomitsopoulos (Author), Kyriakos Kachrimanis (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sildenafil is a potent selective, reversible inhibitor of phosphodiesterase type 5 (PDE5) approved for the treatment of erectile dysfunction and pulmonary arterial hypertension. Whilst twenty years have passed since its original approval by the US Food and Drug Administration (USFDA), sildenafil ent...