Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain

• Main Authors: Vaillancourt François (Author), Lembo Paola MC (Author), Lessard Etienne (Author), Jomphe Claudia (Author), Martino Giovanni (Author), Elmes Steven JR (Author), McIntosh Fraser (Author), Paré Michel (Author), Serrano Alexandre (Author), Perkins Martin N (Author), Cao Chang (Author)
• Format: Book
• Published: SAGE Publishing, 2010-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The CCR2/CCL2 system has been identified as a regulator in the pathogenesis of neuropathy-induced pain. However, CCR2 target validation in analgesia and the mechanism underlying antinociception produced by CCR2 antagonists remains po...