Intracellular Delivery of Anti-SMC2 Antibodies against Cancer Stem Cells

• Main Authors: Sara Montero (Author), Joaquin Seras-Franzoso (Author), Fernanda Andrade (Author), Francesc Martinez-Trucharte (Author), Mireia Vilar-Hernández (Author), Manuel Quesada (Author), Helena Xandri (Author), Diego Arango (Author), Ibane Abasolo (Author), Diana Rafael (Author), Simo Schwartz (Author)
• Format: Book
• Published: MDPI AG, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Structural maintenance of chromosomes protein 2 (SMC2) is a central component of the condensin complex involved in DNA supercoiling, an essential process for embryonic stem cell survival. SMC2 over-expression has been related with tumorigenesis and cancer malignancy and its inhibition is regarded as...