Co-delivery of Bmi1 small interfering RNA with ursolic acid by folate receptor-targeted cationic liposomes enhances anti-tumor activity of ursolic acid in vitro and in vivo

• Main Authors: Weijie Li (Author), Ruicong Yan (Author), Yong Liu (Author), Chuanchuan He (Author), Xiaojuan Zhang (Author), Yao Lu (Author), Muhammad Waseem Khan (Author), Chuanrui Xu (Author), Tan Yang (Author), Guangya Xiang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Overexpression of Bmi1 gene is an important feature of cancer stem cell in various human tumors. Therefore, Bmi1 gene can be a potential target for small interfering RNA (siRNA) mediated cancer therapy. Ursolic acid (UA) as a natural product plays a pivotal role in anti-tumor field, although its per...