Effects of a long-acting secretin peptide analog alone and in combination with a GLP-1R agonist in a diet-induced obesity mouse model

• Main Authors: Mona Loeffler (Author), Katarina Klepac (Author), Angela Baljuls (Author), Bradford Hamilton (Author), Svenja Mayer-Wrangowski (Author), Peter Haebel (Author), Tina Zimmermann (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Obesity is a major global health problem which can be targeted with new mechanistic diverse pharmacological interventions. Here we evaluate a new long-acting secretin receptor agonist as a potential treatment for obesity. Methods: BI-3434 was designed as a secretin analog with stabilized...