In vivo Characterization of a Selective, Orally Available, and Brain Penetrant Small Molecule GPR139 Agonist

• Principais autores: James R. Shoblock (Autor), Natalie Welty (Autor), Ian Fraser (Autor), Ryan Wyatt (Autor), Brian Lord (Autor), Timothy Lovenberg (Autor), Changlu Liu (Autor), Pascal Bonaventure (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2019-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Recently, our group along with another demonstrated that GPR139 can be activated by L-phenylalanine (L-Phe) and L-tryptophan (L-Trp) at physiologically relevant concentrations. GPR139 is discretely expressed in brain, with highest expression in medial habenula. Not only are the endogenous ligands ca...