SARS-CoV-2 spike host cell surface exposure promoted by a COPI sorting inhibitor

• Main Authors: Yiqun Li (Author), Mingrui Yang (Author), Yanan Nan (Author), Jiaming Wang (Author), Sanjiao Wang (Author), Dongxiao Cui (Author), Jiajian Guo (Author), Pengfei He (Author), Wenxin Dai (Author), Shuqi Zhou (Author), Yue Zhang (Author), Wenfu Ma (Author)
• Format: Book
• Published: Elsevier, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Via an insufficient coat protein complex I (COPI) retrieval signal, the majority of SARS-CoV-2 spike (S) is resident in host early secretory organelles and a tiny amount is leaked out in cell surface. Only surface-exposed S can be recognized by B cell receptor (BCR) or anti-S therapeutic monoclonal...