Identification of Koumine as a Translocator Protein 18 kDa Positive Allosteric Modulator for the Treatment of Inflammatory and Neuropathic Pain

• Main Authors: Bojun Xiong (Author), Guilin Jin (Author), Ying Xu (Author), Wenbing You (Author), Yufei Luo (Author), Menghan Fang (Author), Bing Chen (Author), Huihui Huang (Author), Jian Yang (Author), Xu Lin (Author), Changxi Yu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Koumine is an alkaloid that displays notable activity against inflammatory and neuropathic pain, but its therapeutic target and molecular mechanism still need further study. Translocator protein 18 kDa (TSPO) is a vital therapeutic target for pain treatment, and recent research implies that there ma...