RNA-binding protein Ptbp1 regulates alternative splicing and transcriptome in spermatogonia and maintains spermatogenesis in concert with Nanos3

• Main Authors: Manami SENOO (Author), Hiroshi HOZOJI (Author), Yu ISHIKAWA-YAMAUCHI (Author), Takashi TAKIJIRI (Author), Sho OHTA (Author), Tomoyo UKAI (Author), Mio KABATA (Author), Takuya YAMAMOTO (Author), Yasuhiro YAMADA (Author), Masahito IKAWA (Author), Manabu OZAWA (Author)
• Format: Book
• Published: The Society for Reproduction and Development, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PTBP1, a well-conserved RNA-binding protein, regulates cellular development by tuning posttranscriptional mRNA modification such as alternative splicing (AS) or mRNA stabilization. We previously revealed that the loss of Ptbp1 in spermatogonia causes the dysregulation of spermatogenesis, but the mol...