Design, synthesis and biological evaluation of novel 4-anlinoquinazoline derivatives as EGFR inhibitors with the potential to inhibit the gefitinib-resistant nonsmall cell lung cancers

• Những tác giả chính: Caolin Wang (Tác giả), Shan Xu (Tác giả), Liang Peng (Tác giả), Bingliang Zhang (Tác giả), Hong Zhang (Tác giả), Yingying Hu (Tác giả), Pengwu Zheng (Tác giả), Wufu Zhu (Tác giả)
• Định dạng: Sách
• Được phát hành: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

A series of quinazoline derivatives with benzylidene hydrazine carboxamide were designed and synthesised as EGFR inhibitors. Most compounds exhibited exceptional anti-proliferative activity against A549, HepG2, MCF-7 and H1975 cells. Furthermore, six compounds demonstrated excellent inhibition activ...