High-throughput drug screening to investigate blood-brain barrier permeability in vitro with a focus on breast cancer chemotherapeutic agents

• Main Authors: Carolin J. Curtaz (Author), Sophia Wucherpfennig (Author), Emad Al-Masnaea (Author), Saskia-Laureen Herbert (Author), Achim Wöckel (Author), Patrick Meybohm (Author), Malgorzata Burek (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Therapy of cerebral diseases such as brain metastatic breast cancer is still challenging. Due to the blood-brain barrier (BBB), a tight barrier that protects the brain and prevents the passage of many drugs, therapeutically sufficient drug concentrations in the brain are often not achieved. Therefor...