Jak2 Inhibitor AG490 Improved Poststroke Central and Peripheral Inflammation and Metabolic Abnormalities in a Rat Model of Ischemic Stroke

• Main Authors: Ya-Yu Wang (Author), Shih-Yi Lin (Author), Cheng-Yi Chang (Author), Chih-Cheng Wu (Author), Wen-Ying Chen (Author), Su-Lan Liao (Author), Yu-Fan Chen (Author), Wen-Yi Wang (Author), Chun-Jung Chen (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Poststroke hyperglycemia and inflammation have been implicated in the pathogenesis of stroke. Janus Kinase 2 (Jak2), a catalytic signaling component for cytokine receptors such as Interleukin-6 (IL-6), has inflammatory and metabolic properties. This study aimed to investigate the roles of Jak2 in po...