CyPPA, a positive SK3/SK2 modulator, reduces activity of dopaminergic neurons, inhibits dopamine release, and counteracts hyperdopaminergic behaviors induced by methylphenidate

• Main Authors: Kjartan F. Herrik (Author), John P Redrobe (Author), Dorte eHolst (Author), Charlotte eHougaard (Author), Karin S. Nielsen (Author), Alexander N. Nielsen (Author), Huifang eJi (Author), Nina M. Holst (Author), Hanne B. Rasmussen (Author), Elsebet Ø. Nielsen (Author), Dorte eStrøbæk (Author), Paul D. Shepard (Author), Palle eChristophersen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dopamine (DA) containing midbrain neurons play critical roles in several psychiatric and neurological diseases, including schizophrenia and attention deficit hyperactivity disorder (ADHD), and the substantia nigra pars compacta neurons selectively degenerate in Parkinson's disease. Pharmacologi...