Impacts of anti‐inflammatory phosphodiesterase inhibitors on a murine model of chronic pulmonary inflammation

• Main Authors: Xiao‐Fang Zheng (Author), Dan‐Dan Chen (Author), Xiao‐Ling Zhu (Author), Jehane Michael Le Grange (Author), Lu‐Qian Zhou (Author), Jin‐Nong Zhang (Author)
• Format: Book
• Published: Wiley, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Chronic obstructive pulmonary disease (COPD) often tends to respond poorly to glucocorticoid (GC) therapy. Reduced Histone deacetylase‐2 (HDAC‐2) activity is an important mechanism behind this GC insensitivity. In this study, we investigated the effects of three phosphodiesterase inhibitors...