Burkholderia pseudomallei triggers canonical inflammasome activation in a human primary macrophage-based infection model.

• Main Authors: Sabine Lichtenegger (Author), Julia Stiehler (Author), Sabine Saiger (Author), Andrea Zauner (Author), Barbara Kleinhappl (Author), Claudia Bernecker (Author), Peter Schlenke (Author), Gabriel E Wagner (Author), Kathrin Krause (Author), Magdalena Gastager (Author), Ivo Steinmetz (Author)
• Format: Bog
• Udgivet: Public Library of Science (PLoS), 2020-11-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Most of the current knowledge on Burkholderia pseudomallei-induced inflammasome activation and cell death in macrophages is derived from murine systems. Little is known about the involved bacterial structures and mechanisms in primary human macrophages. This is of particular relevance since murine a...