Linker Design Impacts Antibody-Drug Conjugate Pharmacokinetics and Efficacy via Modulating the Stability and Payload Release Efficiency

• Main Authors: Dian Su (Author), Donglu Zhang (Author)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

The development of antibody-drug conjugates (ADCs) has significantly been advanced in the past decade given the improvement of payloads, linkers and conjugation methods. In particular, linker design plays a critical role in modulating ADC stability in the systemic circulation and payload release eff...