Pitfalls of improperly procured adjacent non-neoplastic tissue for somatic mutation analysis using next-generation sequencing

• Main Authors: Lei Wei (Author), Antonios Papanicolau-Sengos (Author), Song Liu (Author), Jianmin Wang (Author), Jeffrey M. Conroy (Author), Sean T. Glenn (Author), Elizabeth Brese (Author), Qiang Hu (Author), Kiersten Marie Miles (Author), Blake Burgher (Author), Maochun Qin (Author), Karen Head (Author), Angela R. Omilian (Author), Wiam Bshara (Author), John Krolewski (Author), Donald L. Trump (Author), Candace S. Johnson (Author), Carl D. Morrison (Author)
• פורמט: ספר
• יצא לאור: BMC, 2016-10-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Abstract Background The rapid adoption of next-generation sequencing provides an efficient system for detecting somatic alterations in neoplasms. The detection of such alterations requires a matched non-neoplastic sample for adequate filtering of non-somatic events such as germline polymorphisms. No...