Synthesis, potential anticonvulsant and antidepressant effects of 2-(5-methyl-2,3-dioxoindolin-1-yl)acetamide derivatives

• Egile Nagusiak: Xinghua Zhen (Egilea), Zhou Peng (Egilea), Shuilian Zhao (Egilea), Yan Han (Egilea), Qinghao Jin (Egilea), Liping Guan (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2015-07-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

A new series of 2-(5-methyl-2,3-dioxoindolin-1-yl)acetamide derivatives were synthesized and evaluated for their anticonvulsive activity in a pentylenetetrazole (PTZ)-evoked convulsion model and antidepressant activity in the forced swimming test (FST) model. Eleven synthesized compounds were found...