Synthesis, potential anticonvulsant and antidepressant effects of 2-(5-methyl-2,3-dioxoindolin-1-yl)acetamide derivatives

• Main Authors: Xinghua Zhen (Author), Zhou Peng (Author), Shuilian Zhao (Author), Yan Han (Author), Qinghao Jin (Author), Liping Guan (Author)
• Format: Book
• Published: Elsevier, 2015-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A new series of 2-(5-methyl-2,3-dioxoindolin-1-yl)acetamide derivatives were synthesized and evaluated for their anticonvulsive activity in a pentylenetetrazole (PTZ)-evoked convulsion model and antidepressant activity in the forced swimming test (FST) model. Eleven synthesized compounds were found...