miR-150-Based RNA Interference Attenuates Tubulointerstitial Fibrosis through the SOCS1/JAK/STAT Pathway In Vivo and In Vitro

• Main Authors: Junjun Luan (Author), Jingqi Fu (Author), Dongdong Wang (Author), Congcong Jiao (Author), Xiangfei Cui (Author), Chengjie Chen (Author), Dan Liu (Author), Yixiao Zhang (Author), Yanqiu Wang (Author), Peter S.T. Yuen (Author), Jeffrey B. Kopp (Author), Jingbo Pi (Author), Hua Zhou (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated whether microRNA-150 (miR-150)-based RNA interference (RNAi) ameliorates tubular injury and tubulointerstitial fibrosis. Mice injected with folic acid developed tubulointerstitial fibrosis at day 30. miR-150 levels were increased at day 7 and peaked at day 30. At day 30, protein leve...