Effects of ʟ-Carnitine Treatment on Kidney Mitochondria and Macrophages in Mice with Diabetic Nephropathy

• Hoofdauteurs: Seigo Ito (Auteur), Masahiro Nakashima (Auteur), Takuya Ishikiriyama (Auteur), Hiroyuki Nakashima (Auteur), Akira Yamagata (Auteur), Toshihiko Imakiire (Auteur), Manabu Kinoshita (Auteur), Shuhji Seki (Auteur), Hiroo Kumagai (Auteur), Naoki Oshima (Auteur)
• Formaat: Boek
• Gepubliceerd in: Karger Publishers, 2022-02-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Introduction: In diabetic nephropathy (DN), mitochondrial dysfunction and leakage of mitochondrial DNA (mtDNA) are caused by the downregulation of superoxide dismutase 2 (SOD2). mtDNA induces the activation of Toll-like receptor (TLR) 9, which is present in macrophages (Mφs) and triggers their activ...