Effects of ʟ-Carnitine Treatment on Kidney Mitochondria and Macrophages in Mice with Diabetic Nephropathy

• Main Authors: Seigo Ito (Author), Masahiro Nakashima (Author), Takuya Ishikiriyama (Author), Hiroyuki Nakashima (Author), Akira Yamagata (Author), Toshihiko Imakiire (Author), Manabu Kinoshita (Author), Shuhji Seki (Author), Hiroo Kumagai (Author), Naoki Oshima (Author)
• Format: Book
• Published: Karger Publishers, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: In diabetic nephropathy (DN), mitochondrial dysfunction and leakage of mitochondrial DNA (mtDNA) are caused by the downregulation of superoxide dismutase 2 (SOD2). mtDNA induces the activation of Toll-like receptor (TLR) 9, which is present in macrophages (Mφs) and triggers their activ...