Heterotrimeric G Protein Gα13-Induced Induction of Cytokine mRNAs Through Two Distinct Pathways in Cardiac Fibroblasts

• Main Authors: Nagamatsu Yuichi (Author), Nishida Motohiro (Author), Onohara Naoya (Author), Fukutomi Masashi (Author), Maruyama Yoshiko (Author), Kobayashi Hiroyuki (Author), Sato Yoji (Author), Kurose Hitoshi (Author)
• Format: Book
• Published: Elsevier, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: Overexpression of constitutively active (CA)-Gα13 significantly increased the expression of interleukin (IL)-1β and IL-6 mRNAs and proteins in rat cardiac fibroblasts. IL-1β mRNA induction by CA-Gα13 was suppressed by diphenyleneiodonium (DPI), an NADPH oxidase inhibitor, but not by BAPTA...