Puerarin-loaded PEG-PE micelles with enhanced anti-apoptotic effect and better pharmacokinetic profile

• Main Authors: Wenqun Li (Author), Junyong Wu (Author), Jiang Zhang (Author), Jingjing Wang (Author), Daxiong Xiang (Author), Shilin Luo (Author), Jianhe Li (Author), Xinyi Liu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Puerarin (PUE) is the most abundant isoflavonoid in kudzu root. It is widely used as a therapeutic agent for the treatment of cardiovascular diseases. However, the short elimination half-life, poor-bioavailability, and acute intravascular hemolysis of PUE are the main obstacles to its widespread cli...