Flat dose regimen of toripalimab based on model-informed drug development approach

• Main Authors: Lili Li (Author), Jianye Qu (Author), Ming Song (Author), Qun Zhao (Author), Yonghua Yang (Author), Xi Tan (Author), Yanyan Hu (Author), Jing Li (Author), Yunfei Lin (Author), Hui Feng (Author), Sheng Yao (Author), Patricia Keegan (Author), Meixia Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Flat dosing regimen has recently been approved for programmed death receptor-1 (PD-1) inhibitors including toripalimab, nivolumab and pembrolizumab. The objective of this study is to provide pharmacological evidence for a flat dosing regimen of toripalimab by assessing the efficacy and...