Scutellarin Suppresses NLRP3 Inflammasome Activation in Macrophages and Protects Mice against Bacterial Sepsis

• Main Authors: Yi Liu (Author), Yan-Yun Jing (Author), Chen-Ying Zeng (Author), Chen-Guang Li (Author), Li-Hui Xu (Author), Liang Yan (Author), Wen-Jing Bai (Author), Qing-Bing Zha (Author), Dong-Yun Ouyang (Author), Xian-Hui He (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The NLRP3 inflammasome plays a critical role in mediating the innate immune defense against pathogenic infections, but aberrant activation of NLRP3 inflammasome has been linked to a variety of inflammatory diseases. Thus targeting the NLRP3 inflammasome represents a promising therapeutic for the tre...