Integration of genomics, clinical characteristics and baseline biological profiles to predict the risk of liver injury induced by high-dose methotrexate

• Main Authors: Chenquan Lin (Author), Rui Ma (Author), Xiao Zeng (Author), Bikui Zhang (Author), Ting Cao (Author), Shimeng Jiao (Author), Hui Chen (Author), Yifang He (Author), Mouze Liu (Author), Hualin Cai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundHigh-dose methotrexate (HD-MTX) is commonly employed in the treatment of malignant tumors in children and young adults due to its distinctive therapeutic efficacy. Nonetheless, the systemic exposure to MTX often results in liver injury (drug induced liver injury, DILI), thereby imposing li...