Population pharmacokinetic/pharmacodynamic analysis of AK111, an IL-17A monoclonal antibody, in subjects with moderate-to-severe plaque psoriasis

• Main Authors: Qian Li (Author), Ju Qiao (Author), Hongzhong Jin (Author), Benchao Chen (Author), Zhimei He (Author), Guoqin Wang (Author), Xiang Ni (Author), Max Wang (Author), Michelle Xia (Author), Baiyong Li (Author), Rui Chen (Author), Pei Hu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AK111 is an innovative IL-17A antibody, presenting high affinity to IL-17A and showing similar pharmacokinetic (PK) characteristics to those of typical immunoglobulin (Ig) G1 antibodies. To optimize the dosage regimen for phase 2/3 clinical trials, PK and pharmacodynamics (PD) of AK111 were first ch...