Structure-activity relationship investigation of tertiary amine derivatives of cinnamic acid as acetylcholinesterase and butyrylcholinesterase inhibitors: compared with that of phenylpropionic acid, sorbic acid and hexanoic acid

• Главные авторы: Xiaohui Gao (Автор), Jingjing Tang (Автор), Haoran Liu (Автор), Linbo Liu (Автор), Lu Kang (Автор), Wen Chen (Автор)
• Формат: ‌
• Опубликовано: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Предметы: article
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In the present investigation, 48 new tertiary amine derivatives of cinnamic acid, phenylpropionic acid, sorbic acid and hexanoic acid (4d-6g, 10d-12g, 16d-18g and 22d-24g) were designed, synthesized and evaluated for the effect on AChE and BChE in vitro. The results revealed that the alteration of a...