Structure-activity relationship investigation of tertiary amine derivatives of cinnamic acid as acetylcholinesterase and butyrylcholinesterase inhibitors: compared with that of phenylpropionic acid, sorbic acid and hexanoic acid

• Asıl Yazarlar: Xiaohui Gao (Yazar), Jingjing Tang (Yazar), Haoran Liu (Yazar), Linbo Liu (Yazar), Lu Kang (Yazar), Wen Chen (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

In the present investigation, 48 new tertiary amine derivatives of cinnamic acid, phenylpropionic acid, sorbic acid and hexanoic acid (4d-6g, 10d-12g, 16d-18g and 22d-24g) were designed, synthesized and evaluated for the effect on AChE and BChE in vitro. The results revealed that the alteration of a...