Immune tolerance promotion by LSEC-specific lentiviral vector-mediated expression of the transgene regulated by the stabilin-2 promoter

• Autores principales: Ester Borroni (Autor), Chiara Borsotti (Autor), Roberta A. Cirsmaru (Autor), Vakhtang Kalandadze (Autor), Rosella Famà (Autor), Simone Merlin (Autor), Brian Brown (Autor), Antonia Follenzi (Autor)
• Formato: Libro
• Publicado: Elsevier, 2024-03-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Liver sinusoidal endothelial cells (LSECs) are specialized endocytic cells that clear the body from blood-borne pathogens and waste macromolecules through scavenger receptors (SRs). Among the various SRs expressed by LSECs is stabilin-2 (STAB2), a class H SR that binds to several ligands, among whic...