Afatinib Reverses EMT via Inhibiting CD44-Stat3 Axis to Promote Radiosensitivity in Nasopharyngeal Carcinoma

• Hoofdauteurs: Huichao Huang (Auteur), Fangling Huang (Auteur), Xujun Liang (Auteur), Ying Fu (Auteur), Zhe Cheng (Auteur), Yan Huang (Auteur), Zhuchu Chen (Auteur), Yankun Duan (Auteur), Yongheng Chen (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2022-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Background: Afatinib, a second-generation tyrosine kinase inhibitor (TKI), exerts its radiosensitive effects in nasopharyngeal carcinoma (NPC). However, the detailed mechanism of afatinib-mediated sensitivity to radiation is still obscure in NPC. Methods: Quantitative phosphorylated proteomics and b...