A Synthetic Cell-Penetrating Peptide Antagonizing TrkA Function Suppresses Neuropathic Pain in Mice

• Main Authors: Wei-Ying Ma (Author), Eri Murata (Author), Koyo Ueda (Author), Yoshihiro Kuroda (Author), Ming-Hui Cao (Author), Mineo Abe (Author), Kenji Shigemi (Author), Munetaka Hirose (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nerve growth factor (NGF) and its high-affinity receptor, TrkA, are one of the targets in the production of new drugs for the treatment of neuropathic pain. NGF contributes to both the initiation and maintenance of sensory abnormalities after peripheral nerve injury. This study examined the effects...