Relationship of MMP-14 and TIMP-3 Expression with Macrophage Activation and Human Atherosclerotic Plaque Vulnerability

• Main Authors: Jason L. Johnson (Author), Nicholas P. Jenkins (Author), Wei-Chun Huang (Author), Karina Di Gregoli (Author), Graciela B. Sala-Newby (Author), Vincent P. W. Scholtes (Author), Frans L. Moll (Author), Gerard Pasterkamp (Author), Andrew C. Newby (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Matrix metalloproteinase-14 (MMP-14) promotes vulnerable plaque morphology in mice, whereas tissue inhibitor of metalloproteinases-3 (TIMP-3) overexpression is protective. MMP-14hi  TIMP-3lo rabbit foam cells are more invasive and more prone to apoptosis than MMP-14lo  TIMP-3hi cells. We investigate...