Relationship of MMP-14 and TIMP-3 Expression with Macrophage Activation and Human Atherosclerotic Plaque Vulnerability

• Hauptverfasser: Jason L. Johnson (Verfasst von), Nicholas P. Jenkins (Verfasst von), Wei-Chun Huang (Verfasst von), Karina Di Gregoli (Verfasst von), Graciela B. Sala-Newby (Verfasst von), Vincent P. W. Scholtes (Verfasst von), Frans L. Moll (Verfasst von), Gerard Pasterkamp (Verfasst von), Andrew C. Newby (Verfasst von)
• Format: Buch
• Veröffentlicht: Hindawi Limited, 2014-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Matrix metalloproteinase-14 (MMP-14) promotes vulnerable plaque morphology in mice, whereas tissue inhibitor of metalloproteinases-3 (TIMP-3) overexpression is protective. MMP-14hi  TIMP-3lo rabbit foam cells are more invasive and more prone to apoptosis than MMP-14lo  TIMP-3hi cells. We investigate...