Tussilagone Inhibits Osteoclastogenesis and Periprosthetic Osteolysis by Suppressing the NF-κB and P38 MAPK Signaling Pathways

• Main Authors: Xuantao Hu (Author), Ziqing Yin (Author), Xia Chen (Author), Guangyao Jiang (Author), Daishui Yang (Author), Ziqin Cao (Author), Shuai Li (Author), Zicheng Liu (Author), Dan Peng (Author), Pengcheng Dou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundAseptic prosthetic loosening is one of the main factors causing poor prognosis of limb function after joint replacement and requires troublesome revisional surgery. It is featured by wear particle-induced periprosthetic osteolysis mediated by excessive osteoclasts activated in inflammatory...