Experimental analysis of bladder cancer-associated mutations in EP300 identifies EP300-R1627W as a driver mutation

Abstract Background Bladder cancer (BCa) is the most common malignant tumor of the urinary system, with transitional cell carcinoma (TCC) being the predominant type. EP300 encodes a lysine acetyltransferase that regulates a large subset of genes by acetylating histones and non-histone proteins. We p...

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Main Authors: Mayao Luo (Author), Yifan Zhang (Author), Zhuofan Xu (Author), Shidong Lv (Author), Qiang Wei (Author), Qiang Dang (Author)
Format: Book
Published: BMC, 2023-01-01T00:00:00Z.
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